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Lenovo launches new ThinkCentre desktop globally with 64 GB RAM and 50 TOPS NPU

The ThinkCentre M75s Gen 6 weighs 4.8 kg and measures 336 x 300 x 89 mm.
ⓘ Lenovo
The ThinkCentre M75s Gen 6 weighs 4.8 kg and measures 336 x 300 x 89 mm.
Lenovo has launched a new desktop PC globally. Featuring a choice of modern AMD Zen 5 processors, the ThinkCentre M75s Gen 6 also includes up to 64 GB of DDR5 RAM, dual PCIe Gen 5 SSDs and a PCIe slot for adding dedicated GPUs. Lenovo has confirmed pricing and availability for two key markets, too.
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Lenovo has finally unveiled a new ThinkCentre M75s desktop. For context, the company equips the older ThinkCentre M75s Gen 5 (curr. $999 on Amazon) with a choice of AMD Ryzen 8000 or AMD Ryzen Pro 8000 processors. By contrast, the new ThinkCentre M75s Gen 6 switches to the Ryzen AI Pro 400 series from AMD's Gorgon Point family.

Specifically, the new ThinkCentre M75s will be available with up to the Ryzen AI 7 Pro 450G. A desktop version of the Ryzen AI 7 Pro 450, the Ryzen AI 7 Pro 450G combines a 50 TOPS NPU with 8 Zen 5 CPU cores and a 65 W TDP on AMD's Socket AM5 platform. Moreover, the 4 nm processor contains a Radeon 860M iGPU.

The ThinkCentre M75s Gen 6 comes with official Windows 11 Home, Windows 11 Pro and Linux Ubuntu support.
ⓘ Lenovo
The ThinkCentre M75s Gen 6 comes with official Windows 11 Home, Windows 11 Pro and Linux Ubuntu support.

However, Lenovo plans to sell the desktop with the Radeon RX 6400 too, a desktop graphics card that blends a Navi 24 GPU with 8 GB of GDDR6 VRAM. Also, the ThinkCentre M75s Gen 6 will be available with up to 64 GB of DDR5-5600 RAM split between two DDR5 UDIM slots. On top of that, the desktop finds itself with a SATA 3.0 slot, dual PCIe Gen 5 (M.2 2280) slots, dual PCIe x1 slots and a single PCIe x16 Gen 4 slot.

Lenovo will release the ThinkCentre M75s Gen 6 in October 2026 across the Eurozone. Currently, the company intends to price the desktop at €1,059, excluding taxes. Meanwhile, the same device should arrive the same month in the US with a $1,489 starting price. Lenovo has not confirmed pricing or availability for other markets yet, though.

ⓘ Lenovo

Source(s)

Lenovo (via press release)

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> Expert reviews and news on laptops, smartphones and tech innovations > News > News Archive > Newsarchive 2026 09 > Lenovo launches new ThinkCentre desktop globally with 64 GB RAM and 50 TOPS NPU
Alex Alderson, 2026-09- 3 (Update: 2026-09- 2)