Both ASUS and MSI appear to be actively working on bringing SAM (Smart Access Memory) support to a wider range of hardware configurations than AMD initially discussed. ASUS motherboard user u/Merich98 claimed to have gotten SAM working on a Ryzen 7 1700 setup. Testing with Doom Eternal showed negligible performance improvements. However, Doom didn't benefit from SAM even when running in a Ryzen 5000 configuration.
Separately, MSI appears to have shared screenshots of SAM working on a Ryzen 3000/GeForce RTX 3080 setup with WCCFTech. This indicates that official BIOS support could arrive soon for MSI users, alongside driver-level support for owners of NVIDIA Ampere graphics cards.
During the Big Navi launch, AMD showcased SAM as a performance-boosting solution for Ryzen 5000/Big Navi setups where the CPU could address all the VRAM on the GPU. During the announcement, it was mentioned that SAM was made possible because of synergies specific to Big Navi and Ryzen 5000, though the technology was based on an underlying PCIe feature called Resizable BAR.
Not long after, NVIDIA announced that it would be bringing Resizable BAR support to Ampere. As of now, it appears that BAR will be coming to a far wider range of hardware configurations than previously expected, meaning more users will be able to benefit from a sizeable performance boost in games like Assassin's Creed: Valhalla.