Nose microrobots successfully treat stubborn sinusitis in lab tests

Swarms of incredibly small robots, each comparable to a speck of dust, are poised to transform how we treat persistent bacterial infections, particularly those nestled deep within the human body’s complex cavities, such as the sinuses. Developed by a collaborative team of researchers from universities across China and Hong Kong, this groundbreaking method aims to overcome barriers that traditional treatments often face.

The core of this advanced therapeutic platform lies in its photocatalytic microrobots. These aren't just any tiny machines; they are meticulously engineered from copper (Cu) single atom–doped bismuth oxoiodide (BiOI). Once injected into the sinus cavity via a slender catheter threaded through the nostril, these CBMR swarms are precisely guided to the infection site using an external magnetic field. Clinicians can track their progress in real-time with the aid of X-ray imaging.

But the real ingenuity comes with the optical fiber-assisted therapy. A separate optical fiber, also inserted into the body, delivers visible light directly to the targeted region. This light serves two purposes:

• Viscosity reduction. The continuous visible-light irradiation generates a photothermal effect, dramatically reducing the viscosity of the highly resistant pus that often encapsulates deep-seated infections. This allows the CBMR swarm to penetrate the inflamed mucosal tissues over three times more efficiently compared to baseline conditions, reaching the heart of the infection.
• Bacterial eradication. Simultaneously, it activates the CBMRs to break bacterial biofilms — the protective material that makes infections so difficult to treat — and produce reactive oxygen species (ROS) to kill the bacteria.

Once their task is complete, these microscopic doctors can be gently expelled from the body, for instance, by being blown out through the nose into a tissue. The effectiveness of this method has already been validated in rigorous vivo trials, using a rabbit sinusitis model. The results were very promising, demonstrating their capability to clear infections with no obvious tissue damage, showcasing their potential for clinical use.

While pre-clinical trials have demonstrated effectiveness, the introduction of this method in clinical use might still be years away — in the meantime, conventional practices will suffice. This sinus pressure relief mask (curr. $35.98 on Amazon), designed for sinusitis, migraine, and headache relief, is one of the products that can help with sinusitis.