Innovative test uncovers hidden DNA-damaging chemicals in common cosmetics and food

Researchers at Justus Liebig University Giessen have introduced a revolutionary testing procedure capable of identifying hidden chemicals that can permanently damage human DNA and harm living cells. Traditional testing methods often missed these dangerous substances in complex mixtures due to solubility issues or interfering laboratory signals. To solve this, the research team developed a new method that isolates individual compounds from complex daily items like teas, perfumes, and cosmetics without needing to know their specific chemical structures in advance.

First, scientists separate a complex mixture into individual spots. Next, they coat this spread-out sample with human liver enzyme systems and reporter bacteria to mimic how the body processes these chemicals. Finally, a special dye is applied that changes color over spots containing genotoxic or reactive substances, helping researchers identify potentially harmful compounds.

The researchers also simulated human liver metabolism to observe how the body processes these chemicals, revealing that our natural detoxification of these substances is surprisingly minimal. By analyzing various everyday goods, the researchers discovered harmful compounds in poorly regulated products like lipsticks, wound creams, and nipple ointments.

The findings emphasize how easily these dangerous substances can bypass natural protective barriers through tiny skin cracks or bleeding gums to enter the bloodstream directly. Additionally, the resulting data corroborates existing health warnings regarding red meat and supports recent European Union bans on smoke flavorings.

Beyond exposing hidden dangers, the updated procedure represents a massive leap in laboratory efficiency. Compared to older safety tests, this new screening is five times faster, drastically cuts down on manual labor, and reduces consumable costs by more than 99%. To help regulatory authorities and manufacturers immediately improve consumer safety, the team designed an affordable, open-source, and miniaturized version of the testing system that can be deployed globally for routine quality control and environmental water monitoring.