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Milestone in AI drug design – first synthetic protein combats resistant bacteria

Researchers at Monash University in Australia have achieved a breakthrough in the fight against multi-resistant germs – with the help of artificial intelligence. (Image source: DallE3)
Researchers at Monash University in Australia have achieved a breakthrough in the fight against multi-resistant germs – with the help of artificial intelligence. (Image source: DallE3)
A team of Australian researchers has used artificial intelligence to design a new type of protein that specifically targets antibiotic-resistant Escherichia coli. The discovery holds strong potential for medical use, though clinical trials to assess its safety and effectiveness are still needed.

For the first time, researchers at Monash University in Australia have completed a fully digital drug development cycle, from molecular modeling to successful lab testing. Published on July 9 in Nature Communications, the breakthrough marks a major step forward in computer-aided drug design. The protein was created by the Monash AI Protein Design Program in Melbourne, which combines deep learning with de novo protein design. The project was led by Dr. Rhys Grinter and A/Prof. Gavin Knott.

The engineered protein uses a highly targeted mechanism: it binds to a specific site on E. coli that’s crucial for iron uptake. Since iron is vital for the bacteria’s survival and reproduction, blocking this pathway causes the cells to die. Lab tests using fluorescent markers confirmed the protein’s effectiveness.

Promising results, but no clinical data yet

The researchers see strong potential for medical use, including the development of new antibiotics, diagnostic tools or vaccines. However, the process remains experimental. Clinical trials to assess safety and effectiveness in humans have yet to begin. Possible risks, such as misuse of publicly available AI tools or unexpected effects in the human body, also need further investigation.

Democratizing research – a key objective

A key goal of the project is to make research more accessible. All tools used are freely available, enabling scientists around the world to apply similar design methods in their own work.

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> Expert Reviews and News on Laptops, Smartphones and Tech Innovations > News > News Archive > Newsarchive 2025 07 > Milestone in AI drug design – first synthetic protein combats resistant bacteria
Marius Müller, 2025-07-10 (Update: 2025-07-10)